Quads!

There appears to be a mistake in the details provided. Nelvana did not produce a show named "Quads!" in 1969. The show "John Callahan's Quads!" was actually released in 2001, created by the Canadian entertainment company Nelvana. Here's a description without any spoilers:

An irreverent, darkly comedic animation, John Callahan's Quads! is an adult-targeted series based on the edgy and controversial works of the late American cartoonist, John Callahan. The show has been lauded for its ability to handle delicate subject matter such as disability, alcoholism, and sexuality with rather surprising humor and audacity.

The storyline revolves around the life of Reilly O'Reilly, a hard-drinking, rude Irishman who is rendered quadriplegic by a car accident caused by his alcoholism. The wealthy, guilt-ridden driver who hit him, a kind-hearted Australian philanthropist named Spalding, gives him a massive mansion out of remorse. The house, nicknamed the 'manor', becomes the central hub where most of the series' events take place.

Reilly lives in the mansion along with a diverse group of characters, who are all victims of Spalding's misguided attempts at goodwill. These individuals, all living with different disabilities, build a unique, dysfunctional family that offers both laughs and lively discussions on social and individual challenges. Reilly himself isn't exactly a role model. He is depicted as grumpy, self-obsessed and without an iota of political correctness. Despite all his flaws, Reilly often ends up being the voice of reason in the crazy, calamitous world of the Quads.

The other primary characters are diverse and interesting in their own right. There's Lefty, a political activist, who lost his limbs in a protest gone wrong. Then we have Fontaine, a former successful poet who suffered brain damage and now speaks solely in gibberish. Blazer, a blind, egotistical ladies' man, and Griz, a transgender Native Canadian mechanic round up the main characters. Other recurring characters constantly add to the dizzying array of eccentricity that runs rife in the manor.

One of the highlights of Quads! is its unfiltered exploration of ableism, prejudice, and the individual struggles that those living with disabilities face. However, it does not do so in a melodramatic or preachy way. The show is instead raw, outspoken, and even ruthless in its comedy, using humor as a powerful critique on societal norms and prejudices. It's a ground-breaking and bold expression of physical disability and chronic conditions portrayed via animation.

Quads! is unique as it does not aim to eloquently handle the representation of disabled people. Instead, it chooses to create humor through the chaotic, stubborn, and often selfish behaviors of its characters. The show openly parodies and satirizes political correctness, making its characters' personalities and relationships far more important than their disabilities.

Furthermore, the animation style of Quads! deserves mention. It successfully captures Callahan's crude drawing style, bringing his distinctive cartoons to life with a two-dimensional, sharp-edged aesthetic. The characters are boldly designed, easily recognizable, and with visible disabilities, reinforcing the show's bluntness regarding their physical conditions.

Quads! aired for two seasons, consisting of 26 episodes, each approximately 22 minutes long. This cult classic is in English, with some portions in gibberish due to one of the character's circumstances. Be warned, this show is not for the faint-hearted. Its humor is brazen and at times provocative, making it suitable for adults who appreciate unconventional comedy.

Packed with unconventional humor, a host of variously disabled yet intriguing characters, and a narrative that refuses to succumb to cliches—Quads! from Nelvana is a display of raw, unapologetic, and boundary-pushing animation.